Insider · CIK 0000898860
Frost Phillip Md Et Al
Files at NNUP (NOCOPI TECHNOLOGIES INC/MD/), OPK (OPKO HEALTH, INC.), COCP (Cocrystal Pharma, Inc.). First filing Nov 13, 2023, latest Aug 6, 2026.
In brief
Frost Phillip Md Et Al files SEC Form 4 as director, 10% owner, CEO and chair at OPK (OPKO HEALTH, INC.), and also at COCP (Cocrystal Pharma, Inc.), NNUP (NOCOPI TECHNOLOGIES INC/MD/). Since Nov 13, 2023, Frost Phillip Md Et Al has reported 33 open-market buys worth $11M and 0 open-market sells worth $0, the latest filed on Aug 6, 2026.
After Frost Phillip Md Et Al's past buys, the stock trailed the S&P 500 by a median 15.8% over six months (n = 30), and 7% of those buys were ahead of the index at six months. InsiderTell labels that a negative record.
The newest scored trade: bought $9,816 of COCP on Aug 5, 2026, filed Aug 6, 2026, scored 18 (weak). In the last 12 months: 14 buys worth $3.5M and 0 sells worth $0.
Where the trades landed
Last year at the 3 companies this insider has traded most, with each buy and sell on the bar it happened.
OPK: OPKO HEALTH, INC.
Daily candles, adjusted for splits and dividends. Green arrows are insider buys, red are sells, sized by value. Click a marked bar to open the signal.Charts by TradingView Lightweight Charts™
COCP: Cocrystal Pharma, Inc.
Daily candles, adjusted for splits and dividends. Green arrows are insider buys, red are sells, sized by value. Click a marked bar to open the signal.Charts by TradingView Lightweight Charts™
NNUP: NOCOPI TECHNOLOGIES INC/MD/
Daily candles, adjusted for splits and dividends. Green arrows are insider buys, red are sells, sized by value. Click a marked bar to open the signal.Charts by TradingView Lightweight Charts™
Signals
This insider’s open-market buys and sells, scored.
| Score | Company | Value | Holdings | Price context | Filed |
|---|---|---|---|---|---|
| 18Weak | COCPbuy Cocrystal Pharma, Inc. | $9,816 10,000 shares | +1% | +24% from low-40% from high | |
| 26Weak | COCPbuy Cocrystal Pharma, Inc. | $71k 75,000 shares | +4% | +15% from low-52% from high | |
| 23Weak | COCPbuy Cocrystal Pharma, Inc. | $20k 20,000 shares | +1% | +16% from low-48% from high | |
| 29Weak | COCPbuy Cocrystal Pharma, Inc. | $47k 50,000 shares | +3% | +13% from low-57% from high | |
| 39Weak | COCPbuy Cocrystal Pharma, Inc. | $47k 50,000 shares | +3% | +9% from low-59% from high | |
| 33Weak | COCPbuy Cocrystal Pharma, Inc. | $19k 20,000 shares | +1% | +6% from low-71% from high | |
| 41Moderate | COCPbuy Cocrystal Pharma, Inc. | $63k 65,000 shares | +4% | +8% from low-70% from high | |
| 10Weak | COCPbuy Cocrystal Pharma, Inc. | $3,975 4,000 shares | +0% | - | |
| 10Weak | COCPbuy Cocrystal Pharma, Inc. | $19k 20,000 shares | +1% | - | |
| 50Moderate | OPKbuy OPKO HEALTH, INC. | $769k 580,000 shares | +0% | +11% from low-32% from high | |
| 60Notable | OPKbuy OPKO HEALTH, INC. | $771k 580,000 shares | +0% | +9% from low-33% from high | |
| 50Moderate | OPKbuy OPKO HEALTH, INC. | $759k 580,000 shares | +0% | +10% from low-32% from high | |
| 59Moderate | OPKbuy OPKO HEALTH, INC. | $679k 533,300 shares | +0% | +8% from low-34% from high | |
| 36Weak | OPKbuy OPKO HEALTH, INC. | $213k 150,000 shares | +0% | +14% from low-30% from high | |
| 56Moderate | OPKbuy OPKO HEALTH, INC. | $891k 675,000 shares | +0% | +5% from low-36% from high | |
| 36Weak | NOCOPI TECHNOLOGIES INC/MD/ | $215k 195,852 shares | +15% | +21% from low-29% from high | |
| 45Moderate | OPKbuy OPKO HEALTH, INC. | $170k 125,000 shares | +0% | 0% from low-30% from high | |
| 46Moderate | OPKbuy OPKO HEALTH, INC. | $185k 125,000 shares | +0% | +4% from low-25% from high | |
| 31Weak | OPKbuy OPKO HEALTH, INC. | $165k 100,000 shares | +0% | +19% from low-14% from high | |
| 33Weak | OPKbuy OPKO HEALTH, INC. | $254k 150,000 shares | +0% | +21% from low-12% from high | |
| 40Moderate | OPKbuy OPKO HEALTH, INC. | $348k 200,000 shares | +0% | - | |
| 35Weak | OPKbuy OPKO HEALTH, INC. | $115k 67,434 shares | +0% | - | |
| 33Weak | OPKbuy OPKO HEALTH, INC. | $70k 47,537 shares | +0% | - | |
| 37Weak | OPKbuy OPKO HEALTH, INC. | $220k 150,000 shares | +0% | - | |
| 46Moderate | OPKbuy OPKO HEALTH, INC. | $741k 500,000 shares | +0% | - | |
| 37Weak | OPKbuy OPKO HEALTH, INC. | $199k 125,000 shares | +0% | - | |
| 47Moderate | OPKbuy OPKO HEALTH, INC. | $781k 500,000 shares | +0% | - | |
| 39Weak | OPKbuy OPKO HEALTH, INC. | $305k 199,072 shares | +0% | - | |
| 36Weak | OPKbuy OPKO HEALTH, INC. | $159k 100,000 shares | +0% | - | |
| 36Weak | OPKbuy OPKO HEALTH, INC. | $422k 280,183 shares | +0% | - | |
| 36Weak | OPKbuy OPKO HEALTH, INC. | $162k 100,000 shares | +0% | - | |
| 36Weak | OPKbuy OPKO HEALTH, INC. | $422k 280,183 shares | +0% | - | |
| 56Moderate | OPKO HEALTH, INC. | $1.3M 1,000,000 shares | +0% | +22% from low-41% from high |
Transactions
The newest 50 of 115 rows this insider has filed.
| Date | Company | Transaction | Shares | Price | Value | Holdings after | Filed |
|---|---|---|---|---|---|---|---|
| Sep 11, 2026 | NNUP NOCOPI TECHNOLOGIES INC/MD/ | AGrant or award Common Stockindirect: See footnote | +21,930 | $0.00 | $0 | 1,511,642 | 29 d ago |
| Aug 5, 2026 | COCP Cocrystal Pharma, Inc. | POpen-market purchase Common Stockindirect: By Frost Gamma Investments Trust | +10,000 | $0.98 | $9,816 | 1,993,551 | Aug 6, 2026 |
| Aug 3, 2026 | COCP Cocrystal Pharma, Inc. | POpen-market purchase Common Stockindirect: By Frost Gamma Investments Trust | +75,000 | $0.94 | $71k | 1,983,551 | Aug 5, 2026 |
| Feb 24, 2026 | COCP Cocrystal Pharma, Inc. | POpen-market purchase Common Stockindirect: By Frost Gamma Investments Trust | +20,000 | $1.00 | $20k | 1,908,551 | Feb 25, 2026 |
| Feb 6, 2026 | COCP Cocrystal Pharma, Inc. | POpen-market purchase Common Stockindirect: By Frost Gamma Investments Trust | +50,000 | $0.95 | $47k | 1,888,551 | Feb 9, 2026 |
| Jan 9, 2026 | COCP Cocrystal Pharma, Inc. | AGrant or award Stock Options (Right to Buy)derivative | +24,615 | $0.00 | $0 | 24,615 | Jan 13, 2026 |
| Dec 31, 2025 | COCP Cocrystal Pharma, Inc. | POpen-market purchase Common Stockindirect: By Frost Gamma Investments Trust | +50,000 | $0.95 | $47k | 1,838,551 | Jan 2, 2026 |
| Dec 30, 2025 | COCP Cocrystal Pharma, Inc. | POpen-market purchase Common Stockindirect: By Frost Gamma Investments Trust | +20,000 | $0.97 | $19k | 1,788,551 | Dec 31, 2025 |
| Dec 24, 2025 | COCP Cocrystal Pharma, Inc. | POpen-market purchase Common Stockindirect: By Frost Gamma Investments Trust | +25,000 | $0.97 | $24k | 1,728,551 | Dec 29, 2025 |
| Dec 26, 2025 | COCP Cocrystal Pharma, Inc. | POpen-market purchase Common Stockindirect: By Frost Gamma Investments Trust | +40,000 | $0.97 | $39k | 1,768,551 | Dec 29, 2025 |
| Nov 26, 2025 | COCP Cocrystal Pharma, Inc. | POpen-market purchase Common Stockindirect: By Frost Gamma Investments Trust | +1,500 | $1.00 | $1,500 | 1,701,051 | Nov 28, 2025 |
| Nov 26, 2025 | COCP Cocrystal Pharma, Inc. | POpen-market purchase Common Stockindirect: By Frost Gamma Investments Trust | +2,500 | $0.99 | $2,475 | 1,703,551 | Nov 28, 2025 |
| Nov 25, 2025 | COCP Cocrystal Pharma, Inc. | POpen-market purchase Common Stockindirect: By Frost Gamma Investments Trust | +20,000 | $0.94 | $19k | 1,699,551 | Nov 25, 2025 |
| Nov 21, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +102,371 | $1.30 | $133k | 216,228,819 | Nov 21, 2025 |
| Nov 21, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +3,894 | $1.32 | $5,140 | 216,232,713 | Nov 21, 2025 |
| Nov 21, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +89,375 | $1.33 | $118k | 216,322,088 | Nov 21, 2025 |
| Nov 21, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +191,490 | $1.33 | $255k | 216,513,578 | Nov 21, 2025 |
| Nov 21, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +192,870 | $1.34 | $257k | 216,706,448 | Nov 21, 2025 |
| Nov 20, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +119,129 | $1.32 | $157k | 215,665,577 | Nov 20, 2025 |
| Nov 20, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +47,105 | $1.33 | $62k | 215,712,682 | Nov 20, 2025 |
| Nov 20, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +211,948 | $1.33 | $282k | 215,924,630 | Nov 20, 2025 |
| Nov 20, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +161,818 | $1.34 | $216k | 216,086,448 | Nov 20, 2025 |
| Nov 20, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +24,579 | $1.34 | $33k | 216,111,027 | Nov 20, 2025 |
| Nov 20, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +1,757 | $1.35 | $2,363 | 216,112,784 | Nov 20, 2025 |
| Nov 20, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +13,664 | $1.35 | $18k | 216,126,448 | Nov 20, 2025 |
| Nov 19, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +36,325 | $1.28 | $46k | 215,002,773 | Nov 19, 2025 |
| Nov 19, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +58,160 | $1.29 | $75k | 215,060,933 | Nov 19, 2025 |
| Nov 19, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +300 | $1.29 | $387 | 215,061,233 | Nov 19, 2025 |
| Nov 19, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +21,236 | $1.30 | $28k | 215,082,469 | Nov 19, 2025 |
| Nov 19, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +30,082 | $1.30 | $39k | 215,112,551 | Nov 19, 2025 |
| Nov 19, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +12,993 | $1.31 | $17k | 215,125,544 | Nov 19, 2025 |
| Nov 19, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +66,504 | $1.31 | $87k | 215,192,048 | Nov 19, 2025 |
| Nov 19, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +198,904 | $1.32 | $262k | 215,390,952 | Nov 19, 2025 |
| Nov 19, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +155,496 | $1.32 | $205k | 215,546,448 | Nov 19, 2025 |
| Nov 18, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +410 | $1.25 | $510 | 214,386,858 | Nov 18, 2025 |
| Nov 18, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +49,590 | $1.25 | $62k | 214,436,448 | Nov 18, 2025 |
| Nov 18, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +66,635 | $1.26 | $84k | 214,503,083 | Nov 18, 2025 |
| Nov 18, 2025 | OPK OPKO HEALTH, INC. | AGrant or award Common Stockindirect: See Footnote | +46,700 | $1.26 | $59k | 214,549,783 | Nov 18, 2025 |
| Nov 18, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +15,000 | $1.27 | $19k | 214,564,783 | Nov 18, 2025 |
| Nov 18, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +1,772 | $1.27 | $2,250 | 214,566,555 | Nov 18, 2025 |
| Nov 18, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +212,608 | $1.28 | $271k | 214,779,163 | Nov 18, 2025 |
| Nov 18, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +69,728 | $1.28 | $89k | 214,848,891 | Nov 18, 2025 |
| Nov 18, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +428 | $1.28 | $550 | 214,849,319 | Nov 18, 2025 |
| Nov 18, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +83,556 | $1.29 | $107k | 214,932,875 | Nov 18, 2025 |
| Nov 18, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +1 | $1.29 | $1 | 214,932,876 | Nov 18, 2025 |
| Nov 18, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +33,572 | $1.29 | $43k | 214,966,448 | Nov 18, 2025 |
| Oct 31, 2025 | OPK OPKO HEALTH, INC. | POpen-market purchase Common Stockindirect: See Footnote | +150,000 | $1.42 | $213k | 214,386,448 | Oct 31, 2025 |
| Oct 28, 2025 | COCP Cocrystal Pharma, Inc. | AGrant or award Common Stockindirect: By Frost Gamma Investments Trust | +359,713 | $1.39 | $500k | 1,679,551 | Oct 30, 2025 |
| Oct 28, 2025 | COCP Cocrystal Pharma, Inc. | AGrant or award Warrantsderivativeindirect: By Frost Gamma Investments Trust | +719,426 | $1.39 | $1.0M | 719,426 | Oct 30, 2025 |
| Sep 11, 2025 | NNUP NOCOPI TECHNOLOGIES INC/MD/ | AGrant or award Common Stockindirect: See footnote | +21,930 | $0.00 | $0 | 1,489,712 | Sep 15, 2025 |
Questions about Frost Phillip Md Et Al
Answered from the filings on this page, as of the latest one.
Is Frost Phillip Md Et Al buying or selling?
In the last 12 months Frost Phillip Md Et Al reported 14 open-market buys worth $3.5M and 0 open-market sells worth $0 on SEC Form 4; the latest was bought $9,816 of COCP on Aug 5, 2026. Grants, option exercises and tax withholding are not counted.
How did Frost Phillip Md Et Al's past buys perform?
Measured from the first close after each filing, the stock trailed the S&P 500 by a median 15.8% over six months across 30 past buys, with 7% ahead of the index. Past results describe what happened; they do not predict the next trade.
Where does Frost Phillip Md Et Al file Form 4?
Frost Phillip Md Et Al has filed Form 4 at OPK (OPKO HEALTH, INC.) as CEO & Chairman; COCP (Cocrystal Pharma, Inc.); NNUP (NOCOPI TECHNOLOGIES INC/MD/). A Form 4 is required of officers, directors and holders of more than 10% of a share class within two business days of a trade.
Not investment advice. Scores and forward returns are decision support built from public SEC filings and past prices; they describe what happened after comparable filings, not what will happen after this one. Do your own research and size your risk.