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buyNotable cluster of 3

Orbimed Advisors LLC bought $14M of UPB

director, owner at Upstream Bio, Inc.. 825,000 shares at an average of $17.00, traded Oct 15, 2024, filed Oct 17, 2024.

Conviction score
65
Value
$14M
825,000 shares
Holdings after
4,554,873
+85% from before
From 52-week low
-
no price yet
From 52-week high
-
no price yet

Score components

  • Role
    Director
    +15
  • Trade size
    $14.0M at market
    +25
  • Relative to holdings
    Holdings up 85%
    +10
  • Price context
    No price history yet
    0
  • Cluster
    3 insiders buying within 14 days
    +15
  • Repeat buying
    First buy in 90 days
    0
  • Track record
    Too few past buys to judge (0 with prices)
    0

What happened after comparable buys

Same side and tier, against the S&P 500, at 1, 3 and 6 months. Shown to Pro users; the whole table is on the backtest page.

This signal so far: 1m +7.9%, 3m -53.9%, 6m -62.8%.

Price around the trade, and since

From a quarter before the trade to today. The arrow is the trade, the circle the day the filing reached EDGAR, which is the first day anyone outside could act; the dotted line is the S&P 500 rebased to that day's close.

UPBOct 9, 2026 · close 4.70
Since filing Oct 17, 2024: -80.1%SPY +36.8% · excess -116.9%

Daily candles, adjusted for splits and dividends. Green arrows are insider buys, red are sells, sized by value; the dashed line is the close on the filing day, the dotted line SPY rebased to it.Charts by TradingView Lightweight Charts™

Rows in this filing

Every transaction in Form 4 0000947871-24-000806, as filed. Open on EDGAR

DateTransactionSharesPriceValueHoldings afterFiled
Oct 15, 2024CConversion
Common Stockindirect: See Footnote
+721,956--973,716Oct 17, 2024
Oct 15, 2024POpen-market purchase
Common Stockindirect: See Footnote
+165,000$17.00$2.8M1,138,716Oct 17, 2024
Oct 15, 2024CConversion
Common Stockindirect: See Footnote
+2,887,833--3,894,873Oct 17, 2024
Oct 15, 2024POpen-market purchase
Common Stockindirect: See Footnote
+660,000$17.00$11M4,554,873Oct 17, 2024
Oct 15, 2024CConversion
Series A redeemable convertible preferred stockderivativeindirect: See Footnote
-524,500--0Oct 17, 2024
Oct 15, 2024CConversion
Series A redeemable convertible preferred stockderivativeindirect: See Footnote
-2,098,000--0Oct 17, 2024
Oct 15, 2024CConversion
Series B redeemable convertible preferred stockderivativeindirect: See Footnote
-197,456--0Oct 17, 2024
Oct 15, 2024CConversion
Series B redeemable convertible preferred stockderivativeindirect: See Footnote
-789,833--0Oct 17, 2024

Related signals

Other insiders at Upstream Bio, Inc. and this insider’s other filings.

ScoreCompanyInsiderValueHoldingsFiled
30Weak
UPBsell 5
Upstream Bio, Inc.
Allison Ambrose
General Counsel
$2,663
485 shares
-3%
30Weak
UPBsell 5
Upstream Bio, Inc.
Aaron Deykin
Chief Medical Officer
$4,914
895 shares
-3%
37Weak
UPBsell 5
Upstream Bio, Inc.
Michael Gray
CFO and COO
$4,683
853 shares
-3%
30Weak
UPBsell 5
Upstream Bio, Inc.
Adam Houghton
Chief Business Officer
$3,843
700 shares
-3%
40Moderate
UPBsell 5
Upstream Bio, Inc.
Everett Rand Sutherland
Chief Executive Officer
$12k
2,095 shares
-3%
40Moderate
UPBbuy 310b5-1
Upstream Bio, Inc.
AI Upstream LLC
owner
$20M
1,175,000 shares
-
65Notable
UPBbuy 3
Upstream Bio, Inc.
Erez Chimovits
director, owner
$14M
825,000 shares
+85%

Not investment advice. Scores and forward returns are decision support built from public SEC filings and past prices; they describe what happened after comparable filings, not what will happen after this one. Do your own research and size your risk.

Orbimed Advisors LLC bought $14M of UPB | InsiderTell