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sellWeak cluster of 210b5-1 plan

David E I Pyott sold $2.2M of ALNY

director at ALNYLAM PHARMACEUTICALS, INC.. 7,440 shares at an average of $299.00, traded Mar 24, 2025, filed Mar 25, 2025.

Warning score
33
Value
$2.2M
7,440 shares
Holdings after
136
-98% from before
From 52-week low
+25%
low $232.27, close $290.70
From 52-week high
-3%
high $300.55, as of Mar 24, 2025

Score components

  • Role
    Director
    +15
  • Trade size
    $2.2M at market
    +25
  • Share of holdings sold
    Sold 98% of holdings
    +20
  • Cluster
    2 insiders selling within 14 days
    +8
  • Exercise and sell
    Shares came from an option exercise in the same filing
    -15
  • 10b5-1 plan
    Pre-scheduled under a 10b5-1 plan
    -20

What happened after comparable sells

Same side and tier, against the S&P 500, at 1, 3 and 6 months. Shown to Pro users; the whole table is on the backtest page.

This signal so far: 1m -13.7%, 3m +15.7%, 6m +61.7%.

Price around the trade, and since

From a quarter before the trade to today. The arrow is the trade, the circle the day the filing reached EDGAR, which is the first day anyone outside could act; the dotted line is the S&P 500 rebased to that day's close.

ALNYOct 9, 2026 · close 232.68
Since filing Mar 25, 2025: -17.2%SPY +37.5% · excess -54.6%

Daily candles, adjusted for splits and dividends. Green arrows are insider buys, red are sells, sized by value; the dashed line is the close on the filing day, the dotted line SPY rebased to it.Charts by TradingView Lightweight Charts™

Rows in this filing

Every transaction in Form 4 0001735276-25-000040, as filed. Open on EDGAR

DateTransactionSharesPriceValueHoldings afterFiled
Mar 24, 2025MOption exercise
Common Stock10b5-1
+7,440$88.95$662k7,576Mar 25, 2025
Mar 24, 2025SOpen-market sale
Common Stock10b5-1
-7,440$299.00$2.2M136Mar 25, 2025
Mar 24, 2025MOption exercise
Stock Option (right to buy)derivative10b5-1
-7,440$0.00$00Mar 25, 2025

Related signals

Other insiders at ALNYLAM PHARMACEUTICALS, INC. and this insider’s other filings.

ScoreCompanyInsiderValueHoldingsFiled
36Weak
ALNYsell
ALNYLAM PHARMACEUTICALS, INC.
Bryan Supran
EVP, CLO and Secretary
$399k
1,758 shares
-12%
25Weak
ALNYsell10b5-1
ALNYLAM PHARMACEUTICALS, INC.
David E I Pyott
director
$1.1M
3,830 shares
-71%
30Weak
ALNYsell10b5-1
ALNYLAM PHARMACEUTICALS, INC.
Melissa McLaughlin
Chief Human Resources Officer
$1.3M
3,910 shares
-29%
26Weak
ALNYsell 510b5-1
ALNYLAM PHARMACEUTICALS, INC.
Kevin Joseph Fitzgerald
CSO & EVP, Head of Research
$418k
1,291 shares
-6%
51Moderate
ALNYsell 5
ALNYLAM PHARMACEUTICALS, INC.
Tolga Tanguler
EVP, Chief Commercial Officer
$746k
2,309 shares
-6%
59Moderate
ALNYsell 5
ALNYLAM PHARMACEUTICALS, INC.
Jeffrey V. Poulton
EVP, Chief Financial Officer
$797k
2,468 shares
-4%
64Notable
ALNYsell 5
ALNYLAM PHARMACEUTICALS, INC.
Yvonne Greenstreet
Chief Executive Officer
$948k
2,933 shares
-3%
40Moderate
ALNYsell 510b5-1
ALNYLAM PHARMACEUTICALS, INC.
Pushkal Garg
EVP Chief R&D
$1.5M
4,713 shares
-20%
65Notable
ALNYsell 5
ALNYLAM PHARMACEUTICALS, INC.
Yvonne Greenstreet
Chief Executive Officer
$2.2M
6,799 shares
-6%
48Moderate
ALNYsell 5
ALNYLAM PHARMACEUTICALS, INC.
Tolga Tanguler
EVP, Chief Commercial Officer
$524k
1,598 shares
-4%

Not investment advice. Scores and forward returns are decision support built from public SEC filings and past prices; they describe what happened after comparable filings, not what will happen after this one. Do your own research and size your risk.

David E I Pyott sold $2.2M of ALNY | InsiderTell