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sellWeak10b5-1 plan

Pamela J. Cramer sold $352k of RYTM

Chief Human Resources Officer at RHYTHM PHARMACEUTICALS, INC.. 3,350 shares at an average of $105.00, traded Nov 20, 2025, filed Nov 24, 2025.

Warning score
0
Value
$352k
3,350 shares
Holdings after
20,814
-14% from before
From 52-week low
+114%
low $46.95, close $100.66
From 52-week high
-12%
high $113.89, as of Nov 20, 2025

Score components

  • Role
    Officer
    +15
  • Trade size
    $352k at market
    +15
  • Share of holdings sold
    Sold 14% of holdings
    +5
  • Cluster
    No other insider selling within 14 days
    0
  • Exercise and sell
    Shares came from an option exercise in the same filing
    -15
  • 10b5-1 plan
    Pre-scheduled under a 10b5-1 plan
    -20

What happened after comparable sells

Same side and tier, against the S&P 500, at 1, 3 and 6 months. Shown to Pro users; the whole table is on the backtest page.

This signal so far: 1m +5.3%, 3m -9.6%, 6m -17.6%.

Price around the trade, and since

From a quarter before the trade to today. The arrow is the trade, the circle the day the filing reached EDGAR, which is the first day anyone outside could act; the dotted line is the S&P 500 rebased to that day's close.

RYTMOct 12, 2026 · close 89.82
Since filing Nov 24, 2025: -15.7%SPY +17.6% · excess -33.3%

Daily candles, adjusted for splits and dividends. Green arrows are insider buys, red are sells, sized by value; the dashed line is the close on the filing day, the dotted line SPY rebased to it.Charts by TradingView Lightweight Charts™

Rows in this filing

Every transaction in Form 4 0001104659-25-115421, as filed. Open on EDGAR

DateTransactionSharesPriceValueHoldings afterFiled
Nov 20, 2025MOption exercise
Common Stock10b5-1
+3,350$27.35$92k24,164Nov 24, 2025
Nov 20, 2025SOpen-market sale
Common Stock10b5-1
-3,350$105.00$352k20,814Nov 24, 2025
Nov 20, 2025MOption exercise
Stock Options (Right to Buy)derivative10b5-1
-3,350$0.00$011,725Nov 24, 2025

Related signals

Other insiders at RHYTHM PHARMACEUTICALS, INC. and this insider’s other filings.

ScoreCompanyInsiderValueHoldingsFiled
28Weak
RYTMsell 210b5-1
RHYTHM PHARMACEUTICALS, INC.
David P Meeker
President and CEO
$5.1M
50,000 shares
-17%
30Weak
RYTMsell 210b5-1
RHYTHM PHARMACEUTICALS, INC.
Hunter C Smith
Chief Financial Officer
$6.6M
62,774 shares
-36%
54Moderate
RYTMsell 410b5-1
RHYTHM PHARMACEUTICALS, INC.
Alastair Garfield
Chief Scientific Officer
$913k
7,763 shares
-77%
20Weak
RYTMsell 410b5-1
RHYTHM PHARMACEUTICALS, INC.
Joseph Shulman
Chief Technical Officer
$608k
5,079 shares
-24%
40Moderate
RYTMsell 410b5-1
RHYTHM PHARMACEUTICALS, INC.
Jennifer Kayden Lee
EVP, Head of North America
$8.9M
75,834 shares
-100%
40Moderate
RYTMsell 410b5-1
RHYTHM PHARMACEUTICALS, INC.
Yann Mazabraud
EVP, Head of International
$6.6M
57,000 shares
-51%
25Weak
RYTMsell10b5-1
RHYTHM PHARMACEUTICALS, INC.
Lynn A. Tetrault
director
$3.7M
37,000 shares
-84%
37Weak
RYTMsell
RHYTHM PHARMACEUTICALS, INC.
Christopher Paul German
Corporate Controller & CAO
$428k
4,643 shares
-100%
38Weak
RYTMsell
RHYTHM PHARMACEUTICALS, INC.
Christopher Paul German
Corporate Controller & CAO
$503k
5,614 shares
-97%
24Weak
RYTMsell10b5-1
RHYTHM PHARMACEUTICALS, INC.
Hunter C Smith
Chief Financial Officer
$806k
7,954 shares
-7%

Not investment advice. Scores and forward returns are decision support built from public SEC filings and past prices; they describe what happened after comparable filings, not what will happen after this one. Do your own research and size your risk.

Pamela J. Cramer sold $352k of RYTM | InsiderTell