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Nasdaq · CIK 0001658551

AMLX Amylyx Pharmaceuticals, Inc.

Insider trading from SEC Form 4. Last filing 5 d ago. Close $28.14 on Oct 9, 2026, +147% from the 52-week low and -29% from the high.

Last 90 days

Net insider value
-$3.8M
more sold than bought
Buys
0
$0 by 0 insiders
Sells
6
$3.8M by 6 insiders
Insiders on file
10
with a Form 4 at this company

Price and insider trades, last year

AMLXOct 9, 2026 · close 28.14

Daily candles, adjusted for splits and dividends. Green arrows are insider buys, red are sells, sized by value. Click a marked bar to open the signal.Charts by TradingView Lightweight Charts™

Signals

Open-market buys and sells at Amylyx Pharmaceuticals, Inc., scored.

ScoreInsiderValueHoldingsPrice contextFiled
18WeakGeorge M Milne Jr
director
sell
$831k
30,000 shares
-4%+144% from low-30% from high
65NotableJustin B. Klee
Co-Chief Executive Officer
sell
$980k
30,464 shares
-1%+182% from low-19% from high
65NotableJoshua B Cohen
Co-Chief Executive Officer
sell
$981k
30,464 shares
-1%+182% from low-19% from high
44ModerateGina Mazzariello
Chief Legal Officer
sell
$310k
9,536 shares
-5%+182% from low-19% from high
52ModerateJames M Frates
Chief Financial Officer
sell
$350k
10,810 shares
-4%+182% from low-19% from high
44ModerateCamille L Bedrosian
Chief Medical Officer
sell
$325k
10,028 shares
-3%+182% from low-19% from high
48ModerateJustin B. Klee
Co-Chief Executive Officer
sell
$74k
21,490 shares
-1%+42% from low-50% from high
48ModerateJoshua B Cohen
Co-Chief Executive Officer
sell
$74k
21,490 shares
-1%+42% from low-50% from high
35WeakGina Mazzariello
Chief Legal Officer
sell
$32k
9,192 shares
-5%+42% from low-50% from high
36WeakCamille L Bedrosian
Chief Medical Officer
sell
$43k
12,425 shares
-6%+42% from low-50% from high
43ModerateJames M Frates
Chief Financial Officer
sell
$38k
10,896 shares
-4%+42% from low-50% from high
37WeakBernhardt G Zeiher
director
buy
$37k
10,000 shares
-+50% from low-47% from high
30WeakGina Mazzariello
Chief Legal Officer
sell
$5,022
1,611 shares
-1%+20% from low-57% from high
40ModerateJoshua B Cohen
Co-Chief Executive Officer
sell
$15k
4,595 shares
-0%+20% from low-57% from high
40ModerateJustin B. Klee
Co-Chief Executive Officer
sell
$14k
4,595 shares
-0%+20% from low-57% from high
30WeakGina Mazzariello
Chief Legal Officer
sell
$13k
4,169 shares
-3%+20% from low-57% from high
46ModerateJustin B. Klee
Co-Chief Executive Officer
sell
$41k
11,855 shares
-0%+37% from low-51% from high
46ModerateJoshua B Cohen
Co-Chief Executive Officer
sell
$41k
11,851 shares
-0%+37% from low-51% from high
30WeakGina Mazzariello
Chief Legal Officer
sell
$13k
3,678 shares
-3%+37% from low-51% from high
38WeakJoshua B Cohen
Co-Chief Executive Officer
sell
$30k
7,471 shares
-0%+57% from low-44% from high
38WeakJustin B. Klee
Co-Chief Executive Officer
sell
$30k
7,471 shares
-0%+57% from low-44% from high
20WeakCamille L Bedrosian
Chief Medical Officer
sell
$30k
5,421 shares
-4%-

Transactions

The last 52 rows filed, every code.

DateInsiderTransactionSharesPriceValueHoldings afterFiled
Oct 5, 2026George M Milne Jr
director
SOpen-market sale
Common Stock10b5-1
-30,000$27.70$831k782,8815 d ago
Sep 10, 2026Justin B. Klee
Co-Chief Executive Officer
SOpen-market sale
Common Stock
-29,025$32.13$933k3,614,49528 d ago
Sep 10, 2026Camille L Bedrosian
Chief Medical Officer
SOpen-market sale
Common Stock
-7,947$32.21$256k280,14528 d ago
Sep 10, 2026James M Frates
Chief Financial Officer
SOpen-market sale
Common Stock
-9,768$32.27$315k234,66728 d ago
Sep 10, 2026Gina Mazzariello
Chief Legal Officer
SOpen-market sale
Common Stock
-9,525$32.46$309k190,84928 d ago
Sep 10, 2026Joshua B Cohen
Co-Chief Executive Officer
SOpen-market sale
Common Stock
-29,545$32.16$950k3,614,04228 d ago
Sep 10, 2026Gina Mazzariello
Chief Legal Officer
SOpen-market sale
Common Stock
-11$33.34$367190,83828 d ago
Sep 10, 2026James M Frates
Chief Financial Officer
SOpen-market sale
Common Stock
-1,042$33.23$35k233,62528 d ago
Sep 10, 2026Justin B. Klee
Co-Chief Executive Officer
SOpen-market sale
Common Stock
-1,439$33.16$48k3,613,05628 d ago
Sep 10, 2026Camille L Bedrosian
Chief Medical Officer
SOpen-market sale
Common Stock
-2,081$33.09$69k278,06428 d ago
Sep 10, 2026Joshua B Cohen
Co-Chief Executive Officer
SOpen-market sale
Common Stock
-919$33.15$30k3,613,12328 d ago
Aug 31, 2026Karen Firestone
director
MOption exercise
Common Stock
+25,000$1.76$44k91,90040 d ago
Aug 31, 2026Karen Firestone
director
MOption exercise
Common Stock
+25,000$5.05$126k116,90040 d ago
Aug 31, 2026Karen Firestone
director
MOption exercise
Stock Option (right to buy)derivative
-25,000$0.00$0040 d ago
Aug 31, 2026Karen Firestone
director
MOption exercise
Stock Option (right to buy)derivative
-25,000$0.00$0040 d ago
Jun 5, 2025George M Milne Jr
director
AGrant or award
Stock Option (right to buy)derivative
+25,000$0.00$025,000Jun 9, 2025
Jun 5, 2025Paul R. Fonteyne
director
AGrant or award
Stock Option (right to buy)derivative
+25,000$0.00$025,000Jun 9, 2025
Jun 5, 2025Karen Firestone
director
AGrant or award
Stock Option (right to buy)derivative
+25,000$0.00$025,000Jun 9, 2025
Jun 5, 2025Daphne Quimi
director
AGrant or award
Stock Option (right to buy)derivative
+25,000$0.00$025,000Jun 9, 2025
Jun 5, 2025Bernhardt G Zeiher
director
AGrant or award
Stock Option (right to buy)derivative
+25,000$0.00$025,000Jun 9, 2025
May 22, 2025Gina Mazzariello
Chief Legal Officer
GGift
Common Stock
-1,000$0.00$0186,969May 27, 2025
Mar 31, 2025Justin B. Klee
Co-Chief Executive Officer
SOpen-market sale
Common Stock
-21,490$3.46$74k3,355,276Apr 2, 2025
Mar 31, 2025Joshua B Cohen
Co-Chief Executive Officer
SOpen-market sale
Common Stock
-21,490$3.47$74k3,355,280Apr 2, 2025
Mar 31, 2025Gina Mazzariello
Chief Legal Officer
SOpen-market sale
Common Stock
-9,192$3.48$32k187,969Apr 2, 2025
Mar 31, 2025Camille L Bedrosian
Chief Medical Officer
SOpen-market sale
Common Stock
-12,425$3.47$43k194,375Apr 2, 2025
Mar 31, 2025James M Frates
Chief Financial Officer
SOpen-market sale
Common Stock
-10,896$3.47$38k290,988Apr 2, 2025
Mar 20, 2025Bernhardt G Zeiher
director
POpen-market purchase
Common Stock
+10,000$3.70$37k10,000Mar 24, 2025
Mar 6, 2025Joshua B Cohen
Co-Chief Executive Officer
AGrant or award
Common Stock
+180,118$0.00$03,376,770Mar 10, 2025
Mar 6, 2025Justin B. Klee
Co-Chief Executive Officer
AGrant or award
Common Stock
+180,118$0.00$03,376,766Mar 10, 2025
Mar 6, 2025Camille L Bedrosian
Chief Medical Officer
AGrant or award
Common Stock
+68,420$0.00$0206,800Mar 10, 2025
Mar 6, 2025Gina Mazzariello
Chief Legal Officer
AGrant or award
Common Stock
+63,851$0.00$0197,161Mar 10, 2025
Mar 6, 2025James M Frates
Chief Financial Officer
AGrant or award
Common Stock
+68,420$0.00$0301,884Mar 10, 2025
Mar 6, 2025Joshua B Cohen
Co-Chief Executive Officer
AGrant or award
Stock Option (Right to Buy)derivative
+270,177$0.00$0270,177Mar 10, 2025
Mar 6, 2025Justin B. Klee
Co-Chief Executive Officer
AGrant or award
Stock Option (right to buy)derivative
+270,177$0.00$0270,177Mar 10, 2025
Mar 6, 2025Camille L Bedrosian
Chief Medical Officer
AGrant or award
Stock Option (Right to Buy)derivative
+102,630$0.00$0102,630Mar 10, 2025
Mar 6, 2025Gina Mazzariello
Chief Legal Officer
AGrant or award
Stock Option (right to buy)derivative
+95,777$0.00$095,777Mar 10, 2025
Mar 6, 2025James M Frates
Chief Financial Officer
AGrant or award
Stock Option (right to buy)derivative
+102,630$0.00$0102,630Mar 10, 2025
Mar 3, 2025Justin B. Klee
Co-Chief Executive Officer
SOpen-market sale
Common Stock
-4,595$3.15$14k3,196,648Mar 5, 2025
Mar 3, 2025Joshua B Cohen
Co-Chief Executive Officer
SOpen-market sale
Common Stock
-4,595$3.17$15k3,196,652Mar 5, 2025
Mar 3, 2025Gina Mazzariello
Chief Legal Officer
SOpen-market sale
Common Stock
-1,611$3.12$5,022133,310Mar 5, 2025
Feb 24, 2025Gina Mazzariello
Chief Legal Officer
SOpen-market sale
Common Stock
-4,169$3.15$13k134,921Feb 26, 2025
Feb 5, 2025Justin B. Klee
Co-Chief Executive Officer
MOption exercise
Common Stock
+36,310$1.57$57k3,201,243Feb 6, 2025
Feb 5, 2025Justin B. Klee
Co-Chief Executive Officer
MOption exercise
Stock Option (right to buy)derivative
-36,310$0.00$00Feb 6, 2025
Feb 3, 2025Justin B. Klee
Co-Chief Executive Officer
SOpen-market sale
Common Stock
-11,855$3.47$41k3,164,933Feb 5, 2025
Feb 3, 2025Joshua B Cohen
Co-Chief Executive Officer
SOpen-market sale
Common Stock
-11,851$3.47$41k3,201,247Feb 5, 2025
Feb 3, 2025Gina Mazzariello
Chief Legal Officer
SOpen-market sale
Common Stock
-3,678$3.49$13k139,090Feb 5, 2025
Jan 24, 2025George M Milne Jr
director
GGift
Common Stock
-27,910$0.00$0830,661Jan 28, 2025
Jan 6, 2025Joshua B Cohen
Co-Chief Executive Officer
SOpen-market sale
Common Stock
-7,471$4.05$30k3,213,098Jan 8, 2025
Jan 6, 2025Justin B. Klee
Co-Chief Executive Officer
SOpen-market sale
Common Stock
-7,471$4.04$30k3,176,788Jan 8, 2025
Dec 2, 2024Camille L Bedrosian
Chief Medical Officer
SOpen-market sale
Common Stock
-5,421$5.54$30k138,380Dec 3, 2024
Nov 4, 2024Justin B. Klee
Co-Chief Executive Officer
MOption exercise
Common Stock
+63,690$1.57$100k3,184,259Nov 6, 2024
Nov 4, 2024Justin B. Klee
Co-Chief Executive Officer
MOption exercise
Stock Option (right to buy)derivative
-63,690$0.00$036,310Nov 6, 2024

Insiders

Everyone who has filed a Form 4 here.

Not investment advice. Scores and forward returns are decision support built from public SEC filings and past prices; they describe what happened after comparable filings, not what will happen after this one. Do your own research and size your risk.

AMLX insider trading: Amylyx Pharmaceuticals, Inc. | InsiderTell