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sellModerate cluster of 710b5-1 plan

Steven George Hughes sold $3.5M of RNA

Chief Medical Officer at Avidity Biosciences, Inc.. 81,434 shares at an average of $42.74, traded Aug 6, 2025, filed Aug 8, 2025.

Warning score
40
Value
$3.5M
81,434 shares
Holdings after
38,867
-97% from before
From 52-week low
-
no price yet
From 52-week high
-
no price yet

Score components

  • Role
    Officer
    +15
  • Trade size
    $3.5M at market
    +25
  • Share of holdings sold
    Sold 97% of holdings
    +20
  • Cluster
    7 insiders selling within 14 days
    +15
  • Exercise and sell
    Shares came from an option exercise in the same filing
    -15
  • 10b5-1 plan
    Pre-scheduled under a 10b5-1 plan
    -20

What happened after comparable sells

Same side and tier, against the S&P 500, at 1, 3 and 6 months. Shown to Pro users; the whole table is on the backtest page.

Price around the trade, and since

From a quarter before the trade to today. The arrow is the trade, the circle the day the filing reached EDGAR, which is the first day anyone outside could act; the dotted line is the S&P 500 rebased to that day's close.

RNAOct 9, 2026 · close 8.40
Since filing Feb 27, 2026: -43.1%SPY +23.8% · excess -66.8%

Daily candles, adjusted for splits and dividends. Green arrows are insider buys, red are sells, sized by value; the dashed line is the close on the filing day, the dotted line SPY rebased to it.Charts by TradingView Lightweight Charts™

Rows in this filing

Every transaction in Form 4 0001599901-25-000150, as filed. Open on EDGAR

DateTransactionSharesPriceValueHoldings afterFiled
Aug 6, 2025MOption exercise
Common Stock10b5-1
+11,283$15.96$180k84,133Aug 8, 2025
Aug 6, 2025SOpen-market sale
Common Stock10b5-1
-11,283$42.74$482k72,850Aug 8, 2025
Aug 6, 2025MOption exercise
Common Stock10b5-1
+12,334$6.57$81k85,184Aug 8, 2025
Aug 6, 2025SOpen-market sale
Common Stock10b5-1
-12,334$42.74$527k72,850Aug 8, 2025
Aug 6, 2025MOption exercise
Common Stock10b5-1
+6,167$22.47$139k79,017Aug 8, 2025
Aug 6, 2025SOpen-market sale
Common Stock10b5-1
-6,167$42.74$264k72,850Aug 8, 2025
Aug 6, 2025MOption exercise
Common Stock10b5-1
+17,667$10.16$179k90,517Aug 8, 2025
Aug 6, 2025SOpen-market sale
Common Stock10b5-1
-17,667$42.74$755k72,850Aug 8, 2025
Aug 6, 2025SOpen-market sale
Common Stock10b5-1
-33,983$42.74$1.5M38,867Aug 8, 2025
Aug 6, 2025MOption exercise
Stock Option (Right to Buy)derivative10b5-1
-11,283$0.00$073,342Aug 8, 2025
Aug 6, 2025MOption exercise
Stock Option (Right to Buy)derivative10b5-1
-12,334$0.00$052,417Aug 8, 2025
Aug 6, 2025MOption exercise
Stock Option (Right to Buy)derivative10b5-1
-6,167$0.00$074,000Aug 8, 2025
Aug 6, 2025MOption exercise
Stock Option (Right to Buy)derivative10b5-1
-17,667$0.00$075,083Aug 8, 2025

Related signals

Other insiders at Avidity Biosciences, Inc. and this insider’s other filings.

ScoreCompanyInsiderValueHoldingsFiled
22Weak
RNAsell 810b5-1
Avidity Biosciences, Inc.
Teresa McCarthy
Chief Human Resources Officer
$212k
2,929 shares
-3%
21Weak
RNAsell 810b5-1
Avidity Biosciences, Inc.
Arthur A Levin
director
$127k
1,758 shares
-10%
32Weak
RNAsell 810b5-1
Avidity Biosciences, Inc.
Michael F MacLean
Chief Financial Officer
$329k
4,542 shares
-7%
27Weak
RNAsell 810b5-1
Avidity Biosciences, Inc.
W. Michael Flanagan
Chief Scientific Officer
$473k
6,534 shares
-7%
45Moderate
RNAsell 810b5-1
Avidity Biosciences, Inc.
Sarah Boyce
President and CEO
$1.0M
14,387 shares
-5%
30Weak
RNAsell 810b5-1
Avidity Biosciences, Inc.
Steven George Hughes
Chief Medical Officer
$355k
4,895 shares
-13%
21Weak
RNAsell 810b5-1
Avidity Biosciences, Inc.
W. Michael Flanagan
Chief Scientific Officer
$171k
2,373 shares
-3%
21Weak
RNAsell 810b5-1
Avidity Biosciences, Inc.
Steven George Hughes
Chief Medical Officer
$171k
2,373 shares
-6%
28Weak
RNAsell 810b5-1
Avidity Biosciences, Inc.
Michael F MacLean
Chief Financial Officer
$143k
1,974 shares
-3%
21Weak
RNAsell 810b5-1
Avidity Biosciences, Inc.
John B Moriarty
Chief Legal Officer
$171k
2,374 shares
-3%

Not investment advice. Scores and forward returns are decision support built from public SEC filings and past prices; they describe what happened after comparable filings, not what will happen after this one. Do your own research and size your risk.

Steven George Hughes sold $3.5M of RNA | InsiderTell