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sellWeak cluster of 710b5-1 plan

Patrick R. O'Neil sold $1.6M of IONS

EVP CLO & General Counsel at IONIS PHARMACEUTICALS INC. 25,300 shares at an average of $64.62, traded Sep 29, 2025, filed Oct 1, 2025.

Warning score
30
Value
$1.6M
25,300 shares
Holdings after
57,130
-37% from before
From 52-week low
+151%
low $25.51, close $64.15
From 52-week high
-0%
high $64.40, as of Sep 29, 2025

Score components

  • Role
    Officer
    +15
  • Trade size
    $1.6M at market
    +25
  • Share of holdings sold
    Sold 37% of holdings
    +10
  • Cluster
    7 insiders selling within 14 days
    +15
  • Exercise and sell
    Shares came from an option exercise in the same filing
    -15
  • 10b5-1 plan
    Pre-scheduled under a 10b5-1 plan
    -20

What happened after comparable sells

Same side and tier, against the S&P 500, at 1, 3 and 6 months. Shown to Pro users; the whole table is on the backtest page.

This signal so far: 1m +12.9%, 3m +20.2%, 6m +14.2%.

Price around the trade, and since

From a quarter before the trade to today. The arrow is the trade, the circle the day the filing reached EDGAR, which is the first day anyone outside could act; the dotted line is the S&P 500 rebased to that day's close.

IONSOct 12, 2026 · close 43.67
Since filing Oct 1, 2025: -33.6%SPY +17.7% · excess -51.3%

Daily candles, adjusted for splits and dividends. Green arrows are insider buys, red are sells, sized by value; the dashed line is the close on the filing day, the dotted line SPY rebased to it.Charts by TradingView Lightweight Charts™

Rows in this filing

Every transaction in Form 4 0000874015-25-000240, as filed. Open on EDGAR

DateTransactionSharesPriceValueHoldings afterFiled
Sep 29, 2025MOption exercise
Common Stock10b5-1
+10,473$56.78$595k67,603Oct 1, 2025
Sep 29, 2025SOpen-market sale
Common Stock10b5-1
-10,473$64.54$676k57,130Oct 1, 2025
Sep 30, 2025MOption exercise
Common Stock10b5-1
+14,827$56.78$842k71,957Oct 1, 2025
Sep 30, 2025SOpen-market sale
Common Stock10b5-1
-14,827$64.68$959k57,130Oct 1, 2025
Sep 29, 2025MOption exercise
Non-Qualified Stock Option (right to buy)derivative10b5-1
-10,473$0.00$045,030Oct 1, 2025
Sep 30, 2025MOption exercise
Non-Qualified Stock Option (right to buy)derivative10b5-1
-14,827$0.00$030,203Oct 1, 2025

Related signals

Other insiders at IONIS PHARMACEUTICALS INC and this insider’s other filings.

ScoreCompanyInsiderValueHoldingsFiled
58Moderate
IONSbuy
IONIS PHARMACEUTICALS INC
Michael R Hayden
director
$1.1M
20,000 shares
+500%
45Moderate
IONSsell 910b5-1
IONIS PHARMACEUTICALS INC
C Frank Bennett
EVP, Chief Scientific Officer
$1.7M
20,536 shares
-25%
38Weak
IONSsell 910b5-1
IONIS PHARMACEUTICALS INC
Allene M. Diaz
director
$864k
10,111 shares
-73%
15Weak
IONSsell 910b5-1
IONIS PHARMACEUTICALS INC
Holly B. Kordasiewicz
EVP, Chief Development Officer
$31k
362 shares
-2%
39Weak
IONSsell 910b5-1
IONIS PHARMACEUTICALS INC
Joseph Klein III
director
$910k
11,518 shares
-51%
32Weak
IONSsell 1010b5-1
IONIS PHARMACEUTICALS INC
Joseph Baroldi
EVP, Chief Business Officer
$452k
5,635 shares
-55%
30Weak
IONSsell 1010b5-1
IONIS PHARMACEUTICALS INC
Eugene Schneider
EVP, Chf Clinical Develop Ofcr
$2.1M
26,000 shares
-25%
23Weak
IONSsell 1010b5-1
IONIS PHARMACEUTICALS INC
Patrick R. O'Neil
EVP CLO & General Counsel
$246k
3,069 shares
-5%
43Moderate
IONSsell 1010b5-1
IONIS PHARMACEUTICALS INC
Eric Swayze
EVP Research
$839k
10,602 shares
-33%
40Moderate
IONSsell 1010b5-1
IONIS PHARMACEUTICALS INC
Brett P Monia
Chief Executive Officer
$6.8M
85,637 shares
-33%

Not investment advice. Scores and forward returns are decision support built from public SEC filings and past prices; they describe what happened after comparable filings, not what will happen after this one. Do your own research and size your risk.

Patrick R. O'Neil sold $1.6M of IONS | InsiderTell