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sellWeak cluster of 410b5-1 plan

Joseph Klein III sold $960k of IONS

director at IONIS PHARMACEUTICALS INC. 12,000 shares at an average of $80.00, traded Nov 25, 2025, filed Nov 28, 2025.

Warning score
39
Value
$960k
12,000 shares
Holdings after
0
-300% from before
From 52-week low
+217%
low $25.51, close $80.93
From 52-week high
0%
high $80.93, as of Nov 25, 2025

Score components

  • Role
    Director
    +15
  • Trade size
    $960k at market
    +24
  • Share of holdings sold
    Sold 100% of holdings
    +20
  • Cluster
    4 insiders selling within 14 days
    +15
  • Exercise and sell
    Shares came from an option exercise in the same filing
    -15
  • 10b5-1 plan
    Pre-scheduled under a 10b5-1 plan
    -20

What happened after comparable sells

Same side and tier, against the S&P 500, at 1, 3 and 6 months. Shown to Pro users; the whole table is on the backtest page.

This signal so far: 1m -3.4%, 3m -1.9%, 6m -7.5%.

Price around the trade, and since

From a quarter before the trade to today. The arrow is the trade, the circle the day the filing reached EDGAR, which is the first day anyone outside could act; the dotted line is the S&P 500 rebased to that day's close.

IONSOct 9, 2026 · close 45.28
Since filing Nov 28, 2025: -45.3%SPY +15.2% · excess -60.4%

Daily candles, adjusted for splits and dividends. Green arrows are insider buys, red are sells, sized by value; the dashed line is the close on the filing day, the dotted line SPY rebased to it.Charts by TradingView Lightweight Charts™

Rows in this filing

Every transaction in Form 4 0000874015-25-000286, as filed. Open on EDGAR

DateTransactionSharesPriceValueHoldings afterFiled
Nov 25, 2025MOption exercise
Common Stockindirect: by Trust10b5-1
+4,000$0.00$04,000Nov 28, 2025
Nov 25, 2025SOpen-market sale
Common Stockindirect: by Trust10b5-1
-4,000$80.00$320k0Nov 28, 2025
Nov 25, 2025MOption exercise
Common Stockindirect: by Trust10b5-1
+4,000$0.00$04,000Nov 28, 2025
Nov 25, 2025SOpen-market sale
Common Stockindirect: by Trust10b5-1
-4,000$80.00$320k0Nov 28, 2025
Nov 25, 2025MOption exercise
Common Stockindirect: by Trust10b5-1
+4,000$0.00$04,000Nov 28, 2025
Nov 25, 2025SOpen-market sale
Common Stockindirect: by Trust10b5-1
-4,000$80.00$320k0Nov 28, 2025
Nov 25, 2025MOption exercise
Non-Qualified Stock Option (right to buy)derivativeindirect: by Trust10b5-1
-4,000$0.00$08,000Nov 28, 2025
Nov 25, 2025MOption exercise
Non-Qualified Stock Option (right to buy)derivativeindirect: by Trust10b5-1
-4,000$0.00$04,000Nov 28, 2025
Nov 25, 2025MOption exercise
Non-Qualified Stock Option (right to buy)derivativeindirect: by Trust10b5-1
-4,000$0.00$00Nov 28, 2025

Related signals

Other insiders at IONIS PHARMACEUTICALS INC and this insider’s other filings.

ScoreCompanyInsiderValueHoldingsFiled
32Weak
IONSsell 710b5-1
IONIS PHARMACEUTICALS INC
Joseph Baroldi
EVP, Chief Business Officer
$452k
5,635 shares
-55%
30Weak
IONSsell 710b5-1
IONIS PHARMACEUTICALS INC
Eugene Schneider
EVP, Chf Clinical Develop Ofcr
$2.1M
26,000 shares
-25%
23Weak
IONSsell 710b5-1
IONIS PHARMACEUTICALS INC
Patrick R. O'Neil
EVP CLO & General Counsel
$246k
3,069 shares
-5%
43Moderate
IONSsell 710b5-1
IONIS PHARMACEUTICALS INC
Eric Swayze
EVP Research
$839k
10,602 shares
-33%
40Moderate
IONSsell 710b5-1
IONIS PHARMACEUTICALS INC
Brett P Monia
Chief Executive Officer
$6.8M
85,637 shares
-33%
14Weak
IONSsell 710b5-1
IONIS PHARMACEUTICALS INC
Spencer R Berthelsen
director
$588k
8,000 shares
-5%
40Moderate
IONSsell 710b5-1
IONIS PHARMACEUTICALS INC
Holly B. Kordasiewicz
EVP, Chief Development Officer
$4.5M
60,846 shares
-73%
7Weak
IONSsell 210b5-1
IONIS PHARMACEUTICALS INC
Spencer R Berthelsen
director
$605k
8,000 shares
-5%
20Weak
IONSsell 310b5-1
IONIS PHARMACEUTICALS INC
Brett P Monia
Chief Executive Officer
$356k
4,536 shares
-2%
40Moderate
IONSsell 410b5-1
IONIS PHARMACEUTICALS INC
Joseph Loscalzo
director
$5.8M
77,289 shares
-68%

Not investment advice. Scores and forward returns are decision support built from public SEC filings and past prices; they describe what happened after comparable filings, not what will happen after this one. Do your own research and size your risk.

Joseph Klein III sold $960k of IONS | InsiderTell