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sellWeak cluster of 210b5-1 plan

Jeffrey M Leiden sold $32M of VRTX

Executive Chairman at VERTEX PHARMACEUTICALS INC / MA. 73,292 shares at an average of $440.60, traded Nov 13, 2025, filed Nov 17, 2025.

Warning score
38
Value
$32M
73,292 shares
Holdings after
24,026
-168% from before
From 52-week low
+19%
low $366.54, close $434.52
From 52-week high
-15%
high $513.76, as of Nov 13, 2025

Score components

  • Role
    Chair
    +20
  • Trade size
    $32.3M at market
    +25
  • Share of holdings sold
    Sold 100% of holdings
    +20
  • Cluster
    2 insiders selling within 14 days
    +8
  • Exercise and sell
    Shares came from an option exercise in the same filing
    -15
  • 10b5-1 plan
    Pre-scheduled under a 10b5-1 plan
    -20

What happened after comparable sells

Same side and tier, against the S&P 500, at 1, 3 and 6 months. Shown to Pro users; the whole table is on the backtest page.

Price around the trade, and since

From a quarter before the trade to today. The arrow is the trade, the circle the day the filing reached EDGAR, which is the first day anyone outside could act; the dotted line is the S&P 500 rebased to that day's close.

VRTXOct 9, 2026 · close 510.08
Since filing Nov 17, 2025: +17.5%SPY +18.2% · excess -0.7%

Daily candles, adjusted for splits and dividends. Green arrows are insider buys, red are sells, sized by value; the dashed line is the close on the filing day, the dotted line SPY rebased to it.Charts by TradingView Lightweight Charts™

Rows in this filing

Every transaction in Form 4 0000875320-25-000234, as filed. Open on EDGAR

DateTransactionSharesPriceValueHoldings afterFiled
Nov 13, 2025MOption exercise
Common Stock10b5-1
+19,688$91.05$1.8M43,714Nov 17, 2025
Nov 13, 2025SOpen-market sale
Common Stock10b5-1
-18,528$440.22$8.2M25,186Nov 17, 2025
Nov 13, 2025SOpen-market sale
Common Stock10b5-1
-1,160$441.05$512k24,026Nov 17, 2025
Nov 14, 2025MOption exercise
Common Stock10b5-1
+13,835$91.05$1.3M37,861Nov 17, 2025
Nov 14, 2025MOption exercise
Common Stock10b5-1
+39,769$86.52$3.4M77,630Nov 17, 2025
Nov 14, 2025SOpen-market sale
Common Stock10b5-1
-32,234$440.30$14M45,396Nov 17, 2025
Nov 14, 2025SOpen-market sale
Common Stock10b5-1
-21,330$441.35$9.4M24,066Nov 17, 2025
Nov 14, 2025SOpen-market sale
Common Stock10b5-1
-40$442.00$18k24,026Nov 17, 2025
Nov 13, 2025MOption exercise
Stock Option (Right to Buy)derivative10b5-1
-19,688$0.00$013,836Nov 17, 2025
Nov 14, 2025MOption exercise
Stock Option (Right to Buy)derivative10b5-1
-13,835$0.00$01Nov 17, 2025
Nov 14, 2025MOption exercise
Stock Option (Right to Buy)derivative10b5-1
-39,769$0.00$063,781Nov 17, 2025

Related signals

Other insiders at VERTEX PHARMACEUTICALS INC / MA and this insider’s other filings.

ScoreCompanyInsiderValueHoldingsFiled
20Weak
VRTXsell10b5-1
VERTEX PHARMACEUTICALS INC / MA
Carmen Bozic
EVP and CMO
$1.1M
2,329 shares
-7%
20Weak
VRTXsell10b5-1
VERTEX PHARMACEUTICALS INC / MA
Carmen Bozic
EVP and CMO
$1.1M
2,329 shares
-6%
35Weak
VRTXsell 610b5-1
VERTEX PHARMACEUTICALS INC / MA
Carmen Bozic
EVP and CMO
$1.1M
2,329 shares
-6%
21Weak
VRTXsell 610b5-1
VERTEX PHARMACEUTICALS INC / MA
Kristen Ambrose
SVP & Chief Accounting Officer
$173k
357 shares
-5%
20Weak
VRTXsell 610b5-1
VERTEX PHARMACEUTICALS INC / MA
Kristen Ambrose
SVP & Chief Accounting Officer
$108k
223 shares
-3%
24Weak
VRTXsell 610b5-1
VERTEX PHARMACEUTICALS INC / MA
Edward Morrow Atkinson III
EVP, Chief Technical Ops. Off.
$325k
668 shares
-3%
27Weak
VRTXsell 610b5-1
VERTEX PHARMACEUTICALS INC / MA
Jonathan Biller
EVP and Chief Legal Officer
$460k
945 shares
-6%
24Weak
VRTXsell 610b5-1
VERTEX PHARMACEUTICALS INC / MA
Mark E. Bunnage
EVP, Chief Scientific Officer
$302k
620 shares
-8%
40Moderate
VRTXsell 610b5-1
VERTEX PHARMACEUTICALS INC / MA
Kristen Ambrose
SVP & Chief Accounting Officer
$1.1M
2,195 shares
-22%
40Moderate
VRTXsell 610b5-1
VERTEX PHARMACEUTICALS INC / MA
Edward Morrow Atkinson III
EVP, Chief Technical Ops. Off.
$1.4M
2,848 shares
-12%

Not investment advice. Scores and forward returns are decision support built from public SEC filings and past prices; they describe what happened after comparable filings, not what will happen after this one. Do your own research and size your risk.

Jeffrey M Leiden sold $32M of VRTX | InsiderTell