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sellWeak cluster of 210b5-1 plan

Samira Shaikhly sold $2.0M of SEPN

Chief People Officer at Septerna, Inc.. 70,453 shares at an average of $28.10, traded Mar 2, 2026, filed Mar 4, 2026.

Warning score
33
Value
$2.0M
70,453 shares
Holdings after
793
-99% from before
From 52-week low
+471%
low $5.02, close $28.64
From 52-week high
-7%
high $30.86, as of Mar 2, 2026

Score components

  • Role
    Officer
    +15
  • Trade size
    $2.0M at market
    +25
  • Share of holdings sold
    Sold 99% of holdings
    +20
  • Cluster
    2 insiders selling within 14 days
    +8
  • Exercise and sell
    Shares came from an option exercise in the same filing
    -15
  • 10b5-1 plan
    Pre-scheduled under a 10b5-1 plan
    -20

What happened after comparable sells

Same side and tier, against the S&P 500, at 1, 3 and 6 months. Shown to Pro users; the whole table is on the backtest page.

This signal so far: 1m -12.6%, 3m +6.0%, 6m +30.1%.

Price around the trade, and since

From a quarter before the trade to today. The arrow is the trade, the circle the day the filing reached EDGAR, which is the first day anyone outside could act; the dotted line is the S&P 500 rebased to that day's close.

SEPNOct 12, 2026 · close 37.56
Since filing Mar 4, 2026: +30.3%SPY +14.4% · excess +15.9%

Daily candles, adjusted for splits and dividends. Green arrows are insider buys, red are sells, sized by value; the dashed line is the close on the filing day, the dotted line SPY rebased to it.Charts by TradingView Lightweight Charts™

Rows in this filing

Every transaction in Form 4 0001193125-26-092050, as filed. Open on EDGAR

DateTransactionSharesPriceValueHoldings afterFiled
Mar 2, 2026MOption exercise
Common Stock10b5-1
+53,714$1.55$83k54,507Mar 4, 2026
Mar 2, 2026MOption exercise
Common Stock10b5-1
+11,638$2.76$32k66,145Mar 4, 2026
Mar 2, 2026MOption exercise
Common Stock10b5-1
+5,101$2.76$14k71,246Mar 4, 2026
Mar 2, 2026SOpen-market sale
Common Stock10b5-1
-4,090$27.51$112k67,156Mar 4, 2026
Mar 2, 2026SOpen-market sale
Common Stock10b5-1
-66,363$28.14$1.9M793Mar 4, 2026
Mar 2, 2026MOption exercise
Stock Option (Right to Buy)derivative10b5-1
-53,714$0.00$015,969Mar 4, 2026
Mar 2, 2026MOption exercise
Stock Option (Right to Buy)derivative10b5-1
-11,638$0.00$03,460Mar 4, 2026
Mar 2, 2026MOption exercise
Stock Option (Right to Buy)derivative10b5-1
-5,101$0.00$05,101Mar 4, 2026

Related signals

Other insiders at Septerna, Inc. and this insider’s other filings.

ScoreCompanyInsiderValueHoldingsFiled
0Weak
SEPNsell10b5-1
Septerna, Inc.
Daniel D. Long
SVP, Drug Discovery
$126k
3,333 shares
-3%
65Notable
SEPNsell 4
Septerna, Inc.
Ra Capital Management, L.p.
director, owner
$63M
1,493,000 shares
-27%
32Weak
SEPNsell 410b5-1
Septerna, Inc.
Third Rock Ventures V, L.P.
owner
$7.4M
147,200 shares
-2%
30Weak
SEPNsell 410b5-1
Septerna, Inc.
Elizabeth Bhatt
President and COO
$1.1M
25,000 shares
-13%
5Weak
SEPNsell 410b5-1
Septerna, Inc.
Daniel D. Long
SVP, Drug Discovery
$115k
3,334 shares
-3%
4Weak
SEPNsell 210b5-1
Septerna, Inc.
Elizabeth Bhatt
President and COO
$136k
4,000 shares
-2%
5Weak
SEPNsell 310b5-1
Septerna, Inc.
Daniel D. Long
SVP, Drug Discovery
$115k
3,333 shares
-3%
16Weak
SEPNsell 210b5-1
Septerna, Inc.
Samira Shaikhly
Chief People Officer
$77k
2,178 shares
-73%
11Weak
SEPNsell 210b5-1
Septerna, Inc.
Daniel D. Long
SVP, Drug Discovery
$533k
15,000 shares
-13%
20Weak
SEPNsell 210b5-1
Septerna, Inc.
Samira Shaikhly
Chief People Officer
$219k
6,250 shares
-89%

Not investment advice. Scores and forward returns are decision support built from public SEC filings and past prices; they describe what happened after comparable filings, not what will happen after this one. Do your own research and size your risk.

Samira Shaikhly sold $2.0M of SEPN | InsiderTell