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sellWeak cluster of 1310b5-1 plan

Joseph Loscalzo sold $962k of IONS

director at IONIS PHARMACEUTICALS INC. 16,000 shares at an average of $60.15, traded Sep 3, 2025, filed Sep 4, 2025.

Warning score
29
Value
$962k
16,000 shares
Holdings after
36,330
-31% from before
From 52-week low
+137%
low $25.51, close $60.49
From 52-week high
0%
high $60.49, as of Sep 3, 2025

Score components

  • Role
    Director
    +15
  • Trade size
    $962k at market
    +24
  • Share of holdings sold
    Sold 31% of holdings
    +10
  • Cluster
    13 insiders selling within 14 days
    +15
  • Exercise and sell
    Shares came from an option exercise in the same filing
    -15
  • 10b5-1 plan
    Pre-scheduled under a 10b5-1 plan
    -20

What happened after comparable sells

Same side and tier, against the S&P 500, at 1, 3 and 6 months. Shown to Pro users; the whole table is on the backtest page.

This signal so far: 1m +16.5%, 3m +37.8%, 6m +26.6%.

Price around the trade, and since

From a quarter before the trade to today. The arrow is the trade, the circle the day the filing reached EDGAR, which is the first day anyone outside could act; the dotted line is the S&P 500 rebased to that day's close.

IONSOct 9, 2026 · close 45.28
Since filing Sep 4, 2025: -23.7%SPY +21.6% · excess -45.3%

Daily candles, adjusted for splits and dividends. Green arrows are insider buys, red are sells, sized by value; the dashed line is the close on the filing day, the dotted line SPY rebased to it.Charts by TradingView Lightweight Charts™

Rows in this filing

Every transaction in Form 4 0000874015-25-000212, as filed. Open on EDGAR

DateTransactionSharesPriceValueHoldings afterFiled
Sep 3, 2025MOption exercise
Common Stock
+16,000$24.42$391k52,330Sep 4, 2025
Sep 3, 2025SOpen-market sale
Common Stock10b5-1
-16,000$60.15$962k36,330Sep 4, 2025
Sep 3, 2025MOption exercise
Non-Qualified Stock Option (right to buy)derivative
-16,000$0.00$00Sep 4, 2025

Related signals

Other insiders at IONIS PHARMACEUTICALS INC and this insider’s other filings.

ScoreCompanyInsiderValueHoldingsFiled
58Moderate
IONSbuy
IONIS PHARMACEUTICALS INC
Michael R Hayden
director
$1.1M
20,000 shares
+500%
45Moderate
IONSsell 910b5-1
IONIS PHARMACEUTICALS INC
C Frank Bennett
EVP, Chief Scientific Officer
$1.7M
20,536 shares
-25%
38Weak
IONSsell 910b5-1
IONIS PHARMACEUTICALS INC
Allene M. Diaz
director
$864k
10,111 shares
-73%
15Weak
IONSsell 910b5-1
IONIS PHARMACEUTICALS INC
Holly B. Kordasiewicz
EVP, Chief Development Officer
$31k
362 shares
-2%
39Weak
IONSsell 910b5-1
IONIS PHARMACEUTICALS INC
Joseph Klein III
director
$910k
11,518 shares
-51%
32Weak
IONSsell 1010b5-1
IONIS PHARMACEUTICALS INC
Joseph Baroldi
EVP, Chief Business Officer
$452k
5,635 shares
-55%
30Weak
IONSsell 1010b5-1
IONIS PHARMACEUTICALS INC
Eugene Schneider
EVP, Chf Clinical Develop Ofcr
$2.1M
26,000 shares
-25%
23Weak
IONSsell 1010b5-1
IONIS PHARMACEUTICALS INC
Patrick R. O'Neil
EVP CLO & General Counsel
$246k
3,069 shares
-5%
43Moderate
IONSsell 1010b5-1
IONIS PHARMACEUTICALS INC
Eric Swayze
EVP Research
$839k
10,602 shares
-33%
40Moderate
IONSsell 1010b5-1
IONIS PHARMACEUTICALS INC
Brett P Monia
Chief Executive Officer
$6.8M
85,637 shares
-33%

Not investment advice. Scores and forward returns are decision support built from public SEC filings and past prices; they describe what happened after comparable filings, not what will happen after this one. Do your own research and size your risk.

Joseph Loscalzo sold $962k of IONS | InsiderTell