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sellModerate cluster of 2

Lauren Mastrocola sold $2.6M of PRAX

Principal Accounting Officer at Praxis Precision Medicines, Inc.. 13,600 shares at an average of $192.08, traded Nov 20, 2025, filed Nov 21, 2025.

Warning score
53
Value
$2.6M
13,600 shares
Holdings after
10,442
-57% from before
From 52-week low
+476%
low $28.47, close $164.09
From 52-week high
-18%
high $201.00, as of Nov 20, 2025

Score components

  • Role
    Officer
    +15
  • Trade size
    $2.6M at market
    +25
  • Share of holdings sold
    Sold 57% of holdings
    +20
  • Cluster
    2 insiders selling within 14 days
    +8
  • Exercise and sell
    Shares came from an option exercise in the same filing
    -15

What happened after comparable sells

Same side and tier, against the S&P 500, at 1, 3 and 6 months. Shown to Pro users; the whole table is on the backtest page.

This signal so far: 1m +60.7%, 3m +97.5%, 6m +102.3%.

Price around the trade, and since

From a quarter before the trade to today. The arrow is the trade, the circle the day the filing reached EDGAR, which is the first day anyone outside could act; the dotted line is the S&P 500 rebased to that day's close.

PRAXOct 14, 2026 · close 239.02
Since filing Nov 21, 2025: +40.8%SPY +18.0% · excess +22.7%

Daily candles, adjusted for splits and dividends. Green arrows are insider buys, red are sells, sized by value; the dashed line is the close on the filing day, the dotted line SPY rebased to it.Charts by TradingView Lightweight Charts™

Rows in this filing

Every transaction in Form 4 0001104659-25-115098, as filed. Open on EDGAR

DateTransactionSharesPriceValueHoldings afterFiled
Nov 20, 2025MOption exercise
Common Stock
+1,047$49.50$52k11,489Nov 21, 2025
Nov 20, 2025MOption exercise
Common Stock
+508$83.85$43k11,997Nov 21, 2025
Nov 20, 2025MOption exercise
Common Stock
+1,557$133.65$208k13,554Nov 21, 2025
Nov 20, 2025MOption exercise
Common Stock
+2,680$43.37$116k16,234Nov 21, 2025
Nov 20, 2025MOption exercise
Common Stock
+207$44.40$9,19116,441Nov 21, 2025
Nov 20, 2025MOption exercise
Common Stock
+2,351$44.40$104k18,792Nov 21, 2025
Nov 20, 2025MOption exercise
Common Stock
+5,250$56.94$299k24,042Nov 21, 2025
Nov 20, 2025SOpen-market sale
Common Stock
-11,455$191.96$2.2M12,587Nov 21, 2025
Nov 20, 2025SOpen-market sale
Common Stock
-2,145$192.71$413k10,442Nov 21, 2025
Nov 20, 2025MOption exercise
Stock Option (Right to Buy)derivative
-1,047$0.00$00Nov 21, 2025
Nov 20, 2025MOption exercise
Stock Option (Right to Buy)derivative
-508$0.00$00Nov 21, 2025
Nov 20, 2025MOption exercise
Stock Option (Right to Buy)derivative
-1,557$0.00$00Nov 21, 2025
Nov 20, 2025MOption exercise
Stock Option (Right to Buy)derivative
-2,680$0.00$09,320Nov 21, 2025
Nov 20, 2025MOption exercise
Stock Option (Right to Buy)derivative
-207$0.00$00Nov 21, 2025
Nov 20, 2025MOption exercise
Stock Option (Right to Buy)derivative
-2,351$0.00$0981Nov 21, 2025
Nov 20, 2025MOption exercise
Stock Option (Right to Buy)derivative
-5,250$0.00$011,376Nov 21, 2025

Related signals

Other insiders at Praxis Precision Medicines, Inc. and this insider’s other filings.

ScoreCompanyInsiderValueHoldingsFiled
25Weak
PRAXsell10b5-1
Praxis Precision Medicines, Inc.
Jill DeSimone
director
$3.6M
11,600 shares
-83%
53Moderate
PRAXsell 2
Praxis Precision Medicines, Inc.
Alex Nemiroff
General Counsel and Secretary
$4.9M
25,130 shares
-55%
42Moderate
PRAXsell
Praxis Precision Medicines, Inc.
Adage Capital Management, L.P.
owner
$33M
313,910 shares
-13%
34Weak
PRAXsell 2
Praxis Precision Medicines, Inc.
Lauren Mastrocola
Principal Accounting Officer
$424k
5,188 shares
-48%
38Weak
PRAXsell 2
Praxis Precision Medicines, Inc.
Alex Nemiroff
General Counsel and Secretary
$661k
8,239 shares
-44%
39Weak
PRAXbuy
Praxis Precision Medicines, Inc.
Marcio Souza
Chief Executive Officer
$11k
10,000 shares
+29%
61Notable
PRAXbuy 3
Praxis Precision Medicines, Inc.
Timothy Edwin Kelly
Chief Financial Officer
$6,998
8,000 shares
+21%
61Notable
PRAXbuy 3
Praxis Precision Medicines, Inc.
Timothy Edwin Kelly
Chief Financial Officer
$6,998
8,000 shares
+21%
64Notable
PRAXbuy 3
Praxis Precision Medicines, Inc.
Dean J Mitchell
director
$42k
50,000 shares
+200%
71Notable
PRAXbuy 3
Praxis Precision Medicines, Inc.
Marcio Souza
Chief Executive Officer
$60k
70,002 shares
+37%

Not investment advice. Scores and forward returns are decision support built from public SEC filings and past prices; they describe what happened after comparable filings, not what will happen after this one. Do your own research and size your risk.

Lauren Mastrocola sold $2.6M of PRAX | InsiderTell