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sellModerate cluster of 310b5-1 plan

Michael Thomas Henderson sold $2.0M of SYRE

director at Spyre Therapeutics, Inc.. 20,000 shares at an average of $100.00, traded Jun 22, 2026, filed Jun 23, 2026.

Warning score
40
Value
$2.0M
20,000 shares
Holdings after
68,606
-23% from before
From 52-week low
+583%
low $14.68, close $100.32
From 52-week high
0%
high $100.32, as of Jun 22, 2026

Score components

  • Role
    Director
    +15
  • Trade size
    $2.0M at market
    +25
  • Share of holdings sold
    Sold 23% of holdings
    +5
  • Cluster
    3 insiders selling within 14 days
    +15
  • 10b5-1 plan
    Pre-scheduled under a 10b5-1 plan
    -20

What happened after comparable sells

Same side and tier, against the S&P 500, at 1, 3 and 6 months. Shown to Pro users; the whole table is on the backtest page.

Price around the trade, and since

From a quarter before the trade to today. The arrow is the trade, the circle the day the filing reached EDGAR, which is the first day anyone outside could act; the dotted line is the S&P 500 rebased to that day's close.

SYREOct 9, 2026 · close 85.69
Since filing Jun 23, 2026: -11.7%SPY +6.4% · excess -18.1%

Daily candles, adjusted for splits and dividends. Green arrows are insider buys, red are sells, sized by value; the dashed line is the close on the filing day, the dotted line SPY rebased to it.Charts by TradingView Lightweight Charts™

Rows in this filing

Every transaction in Form 4 0001636282-26-000084, as filed. Open on EDGAR

DateTransactionSharesPriceValueHoldings afterFiled
Jun 22, 2026SOpen-market sale
Common Stock10b5-1
-20,000$100.00$2.0M68,606Jun 23, 2026

Related signals

Other insiders at Spyre Therapeutics, Inc. and this insider’s other filings.

ScoreCompanyInsiderValueHoldingsFiled
37Weak
SYREsell 310b5-1
Spyre Therapeutics, Inc.
Scott L Burrows
Chief Financial Officer
$2.3M
25,000 shares
-26%
40Moderate
SYREsell 310b5-1
Spyre Therapeutics, Inc.
Heidy King-Jones
See Remarks
$2.6M
28,933 shares
-91%
45Moderate
SYREsell 310b5-1
Spyre Therapeutics, Inc.
Cameron Turtle
Chief Executive Officer
$1.4M
15,000 shares
-3%
32Weak
SYREsell 310b5-1
Spyre Therapeutics, Inc.
Scott L Burrows
Chief Financial Officer
$2.3M
25,732 shares
-24%
40Moderate
SYREsell 310b5-1
Spyre Therapeutics, Inc.
Heidy King-Jones
See Remarks
$2.5M
28,399 shares
-92%
45Moderate
SYREsell 310b5-1
Spyre Therapeutics, Inc.
Cameron Turtle
Chief Executive Officer
$1.3M
15,000 shares
-3%
52Moderate
SYREsell 3
Spyre Therapeutics, Inc.
Scott L Burrows
Chief Financial Officer
$1.3M
15,000 shares
-13%
75Notable
SYREsell 3
Spyre Therapeutics, Inc.
Fairmount Funds Management LLC
director
$400M
4,684,781 shares
-100%
5Weak
SYREsell10b5-1
Spyre Therapeutics, Inc.
Scott L Burrows
Chief Financial Officer
$533k
7,500 shares
-7%
38Weak
SYREsell 210b5-1
Spyre Therapeutics, Inc.
Michael Thomas Henderson
director
$6.0M
80,000 shares
-47%

Not investment advice. Scores and forward returns are decision support built from public SEC filings and past prices; they describe what happened after comparable filings, not what will happen after this one. Do your own research and size your risk.