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sellModerate cluster of 410b5-1 plan

Sheldon Sloan sold $5.6M of SYRE

Chief Medical Officer at Spyre Therapeutics, Inc.. 78,333 shares at an average of $71.50, traded May 1, 2026, filed May 1, 2026.

Warning score
40
Value
$5.6M
78,333 shares
Holdings after
0
-100% from before
From 52-week low
+455%
low $12.51, close $69.42
From 52-week high
-7%
high $74.45, as of May 1, 2026

Score components

  • Role
    Officer
    +15
  • Trade size
    $5.6M at market
    +25
  • Share of holdings sold
    Sold 100% of holdings
    +20
  • Cluster
    4 insiders selling within 14 days
    +15
  • Exercise and sell
    Shares came from an option exercise in the same filing
    -15
  • 10b5-1 plan
    Pre-scheduled under a 10b5-1 plan
    -20

What happened after comparable sells

Same side and tier, against the S&P 500, at 1, 3 and 6 months. Shown to Pro users; the whole table is on the backtest page.

Price around the trade, and since

From a quarter before the trade to today. The arrow is the trade, the circle the day the filing reached EDGAR, which is the first day anyone outside could act; the dotted line is the S&P 500 rebased to that day's close.

SYREOct 13, 2026 · close 80.45
Since filing May 1, 2026: +15.9%SPY +8.5% · excess +7.4%

Daily candles, adjusted for splits and dividends. Green arrows are insider buys, red are sells, sized by value; the dashed line is the close on the filing day, the dotted line SPY rebased to it.Charts by TradingView Lightweight Charts™

Rows in this filing

Every transaction in Form 4 0002038798-26-000004, as filed. Open on EDGAR

DateTransactionSharesPriceValueHoldings afterFiled
May 1, 2026MOption exercise
Common Stock10b5-1
+78,333$27.46$2.2M78,333May 1, 2026
May 1, 2026SOpen-market sale
Common Stock10b5-1
-21,306$69.53$1.5M57,027May 1, 2026
May 1, 2026SOpen-market sale
Common Stock10b5-1
-19,656$70.61$1.4M37,371May 1, 2026
May 1, 2026SOpen-market sale
Common Stock10b5-1
-8,777$71.56$628k28,594May 1, 2026
May 1, 2026SOpen-market sale
Common Stock10b5-1
-12,777$72.94$932k15,817May 1, 2026
May 1, 2026SOpen-market sale
Common Stock10b5-1
-10,358$73.74$764k5,459May 1, 2026
May 1, 2026SOpen-market sale
Common Stock10b5-1
-5,059$74.60$377k400May 1, 2026
May 1, 2026SOpen-market sale
Common Stock10b5-1
-400$75.37$30k0May 1, 2026
May 1, 2026MOption exercise
Stock Option (Right to Buy)derivative10b5-1
-78,333$0.00$0321,667May 1, 2026

Related signals

Other insiders at Spyre Therapeutics, Inc. and this insider’s other filings.

ScoreCompanyInsiderValueHoldingsFiled
37Weak
SYREsell 310b5-1
Spyre Therapeutics, Inc.
Scott L Burrows
Chief Financial Officer
$2.3M
25,000 shares
-26%
40Moderate
SYREsell 310b5-1
Spyre Therapeutics, Inc.
Heidy King-Jones
See Remarks
$2.6M
28,933 shares
-91%
45Moderate
SYREsell 310b5-1
Spyre Therapeutics, Inc.
Cameron Turtle
Chief Executive Officer
$1.4M
15,000 shares
-3%
32Weak
SYREsell 310b5-1
Spyre Therapeutics, Inc.
Scott L Burrows
Chief Financial Officer
$2.3M
25,732 shares
-24%
40Moderate
SYREsell 310b5-1
Spyre Therapeutics, Inc.
Heidy King-Jones
See Remarks
$2.5M
28,399 shares
-92%
45Moderate
SYREsell 310b5-1
Spyre Therapeutics, Inc.
Cameron Turtle
Chief Executive Officer
$1.3M
15,000 shares
-3%
40Moderate
SYREsell 310b5-1
Spyre Therapeutics, Inc.
Jeffrey W. Albers
director
$2.4M
23,000 shares
-460%
23Weak
SYREsell 310b5-1
Spyre Therapeutics, Inc.
Scott L Burrows
Chief Financial Officer
$717k
7,500 shares
-7%
45Moderate
SYREsell 310b5-1
Spyre Therapeutics, Inc.
Cameron Turtle
Chief Executive Officer
$1.4M
15,000 shares
-3%
22Weak
SYREsell 510b5-1
Spyre Therapeutics, Inc.
Scott L Burrows
Chief Financial Officer
$658k
7,500 shares
-7%

Not investment advice. Scores and forward returns are decision support built from public SEC filings and past prices; they describe what happened after comparable filings, not what will happen after this one. Do your own research and size your risk.

Sheldon Sloan sold $5.6M of SYRE | InsiderTell